nanoimmunotech performs biological characterisation of nanoparticles in order to assess their biocompatibility by considering:

	BIOCOMPATIBILITY Nanostructures can interact withbiological systems (serum proteins, complement, corporal fluids, cells). Before their use in vivo, they should be tested in order to know their biocompatibility.
	TOXICITY Nanostructures can induce body toxicity. Several elements such as charge, size, composition, shape, coating... can influence their toxicity capacity. nanoimmunotech offers several tecniques in order to know the toxicity of nanoparticles.
	STERILITY Nanostructures intended to be used in vivo must  be sterile. However, many procedures of Nps synthesis do not take this issue into account. nanoimmunotech offers advice in the method of sterilization to be used for each Np because it is crucial in order to maintain its stability.
	IMMUNOGENICITY Nanostructures can induce immune responses (inflammation, phagocytosis, allergy…). nanoimmunotech offers several methods in order to study the immunogenicity.

Papers developed by NIT:

Sterilization matters: consequences of different sterilization techniques on gold nanoparticles.
França A, Pelaz B, Moros M, Sánchez-Espinel C, Hernández A, Fernández-López C, Grazú V, de la Fuente JM, Pastoriza-Santos I, Liz-Marzán LM, González-Fernández A.
Small. 2010 Jan;6(1):89-95.

Previous experience of nanoimmunotech team:

Surface engineered PLGA Nanoparticles for Intracellular Delivery: Uptake and Cytoxicity - A Confocal Raman Microscopy Study.
Moya, Sergio; Romero, Gabriela; Rojas, Elena; Donath, Edwin; González, África; Estrela-Lopis, Irina; Gao, Changyou; Zhou, Jie; Sánchez, Christian; Franco, Ana.
Biomacromolecules, 11: 2993-2999 (2010)

Nanoparticles and the immune system.
Zolnik BS, González-Fernández Á, Sadrieh N, Dobrovolskaia MA.
Endocrinology. 2010 Feb;151(2):458-65. Epub 2009 Dec 16.

Antibody-Conjugated Nanoparticles for Biomedical Applications.
Manuel Arruebo, Mónica Valladares, and González-Fernández A.
Journal of Nanomaterials, vol. 2009, Article ID 439389, 24 pages, 2009.

Assessing methods for blood cell cytotoxic responses to inorganic nanoparticles and nanoparticle aggregates.
Díaz B, Sánchez-Espinel C, Arruebo M, Faro J, de Miguel E, Magadán S, Yagüe C, Fernández-Pacheco R, Ibarra MR, Santamaría J, González-Fernández A.
Small. 2008 Nov;4(11):2025-34.